Insulin resistant diabetes mellitus in association with haemochromatosis.

INSULIN resistance in association with primary haemochromatosis has been reported on several occasions previously (Allen and Constam, 1929; Root, 1929; Wood and Fitzhugh, 1929; Engel, 1934; Eskind, Franklin and Lowell, 1953; Colwell and Weiger, 1956; Darnaud, Denard, Moreau, Voisin and Pujol, 1958; Uhry, Marcel and Cohen, 1958; Justin-Besancon, Pequignot, Deuil, Etienne, Magdelaine and Jullien, 1960; Michon, Larcan, Hurlet and Vert, 1961). The presence of antibodies to exogenous insulin have been demonstrated in two well documented cases (Eskind, Franklin and Lowell, 1953; Colwell and Weiger, 1956). So far as the author has been able to ascertain, this is the first case in which the "albumin associated" insulin antagonist described by Vallance Owen, Dennes and Campbell (1958) has been estimated. It was present in normal amounts.